Epigenetics as a first exit problem

We develop a framework to discuss stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage, which is known to exhibit exceptionally large stability. The formalism defines a quantative measure of robustness of inherited states. In contrast to Kramers' well-known problem of escape from a potential well, the stability of inherited states in our formulation is not a numerically trivial problem. The most likely exit path does not go along a steepest decent of a potential -- there is no potential. Instead, such a path can be described as a zero-energy trajectory between two equilibria in an auxiliary classical mechanical system. Finding it is similar to e.g. computing heteroclinic orbits in celestial mechanics. The overall lesson of this study is that an examination of equilibria and their bifurcations with changing parameter values allow us to quantify both the stability and the robustness of particular states of a genetic control system.Comment: 6 pages, 3 figures, in REVTe

A general methodology to price and hedge derivatives in incomplete markets

We introduce and discuss a general criterion for the derivative pricing in the general situation of incomplete markets, we refer to it as the No Almost Sure Arbitrage Principle. This approach is based on the theory of optimal strategy in repeated multiplicative games originally introduced by Kelly. As particular cases we obtain the Cox-Ross-Rubinstein and Black-Scholes in the complete markets case and the Schweizer and Bouchaud-Sornette as a quadratic approximation of our prescription. Technical and numerical aspects for the practical option pricing, as large deviation theory approximation and Monte Carlo computation are discussed in detail.Comment: 24 pages, LaTeX, epsfig.sty, 5 eps figures, changes in the presentation of the method, submitted to International J. of Theoretical and Applied Financ

On the dynamics of a self-gravitating medium with random and non-random initial conditions

The dynamics of a one-dimensional self-gravitating medium, with initial density almost uniform is studied. Numerical experiments are performed with ordered and with Gaussian random initial conditions. The phase space portraits are shown to be qualitatively similar to shock waves, in particular with initial conditions of Brownian type. The PDF of the mass distribution is investigated.Comment: Latex, figures in eps, 23 pages, 11 figures. Revised versio

Trace formula for noise corrections to trace formulas

We consider an evolution operator for a discrete Langevin equation with a strongly hyperbolic classical dynamics and Gaussian noise. Using an integral representation of the evolution operator we investigate the high order corrections to the trace of arbitary power of the operator. The asymptotic behaviour is found to be controlled by sub-dominant saddle points previously neglected in the perturbative expansion. We show that a trace formula can be derived to describe the high order noise corrections.Comment: 4 pages, 2 figure

Statistical Mechanics of Shell Models for 2D-Turbulence

We study shell models that conserve the analogues of energy and enstrophy, hence designed to mimic fluid turbulence in 2D. The main result is that the observed state is well described as a formal statistical equilibrium, closely analogous to the approach to two-dimensional ideal hydrodynamics of Onsager, Hopf and Lee. In the presence of forcing and dissipation we observe a forward flux of enstrophy and a backward flux of energy. These fluxes can be understood as mean diffusive drifts from a source to two sinks in a system which is close to local equilibrium with Lagrange multipliers (``shell temperatures'') changing slowly with scale. The dimensional predictions on the power spectra from a supposed forward cascade of enstrophy, and from one branch of the formal statistical equilibrium, coincide in these shell models at difference to the corresponding predictions for the Navier-Stokes and Euler equations in 2D. This coincidence have previously led to the mistaken conclusion that shell models exhibit a forward cascade of enstrophy.Comment: 25 pages + 9 figures, TeX dialect: RevTeX 3.

On the decay of Burgers turbulence

This work is devoted to the decay ofrandom solutions of the unforced Burgers equation in one dimension in the limit of vanishing viscosity. The initial velocity is homogeneous and Gaussian with a spectrum proportional to $k^n$ at small wavenumbers $k$ and falling off quickly at large wavenumbers. In physical space, at sufficiently large distances, there is an ``outer region'', where the velocity correlation function preserves exactly its initial form (a power law) when $n$ is not an even integer. When $1<n<2$ the spectrum, at long times, has three scaling regions : first, a $|k|^n$ region at very small $k$\ms1 with a time-independent constant, stemming from this outer region, in which the initial conditions are essentially frozen; second, a $k^2$ region at intermediate wavenumbers, related to a self-similarly evolving ``inner region'' in physical space and, finally, the usual $k^{-2}$ region, associated to the shocks. The switching from the $|k|^n$ to the $k^2$ region occurs around a wave number $k_s(t) \propto t^{-1/[2(2-n)]}$, while the switching from $k^2$ to $k^{-2}$ occurs around $k_L(t)\propto t^{-1/2}$ (ignoring logarithmic corrections in both instances). The key element in the derivation of the results is an extension of the Kida (1979) log-corrected $1/t$ law for the energy decay when $n=2$ to the case of arbitrary integer or non-integer $n>1$. A systematic derivation is given in which both the leading term and estimates of higher order corrections can be obtained. High-resolution numerical simulations are presented which support our findings.Comment: In LaTeX with 11 PostScript figures. 56 pages. One figure contributed by Alain Noullez (Observatoire de Nice, France

Drifter dispersion in the Adriatic Sea: Lagrangian data and chaotic model

International audienceWe analyze characteristics of drifter trajectories from the Adriatic Sea with recently introduced nonlinear dynamics techniques. We discuss how in quasi-enclosed basins, relative dispersion as a function of time, a standard analysis tool in this context, may give a distorted picture of the dynamics. We further show that useful information may be obtained by using two related non-asymptotic indicators, the Finite-Scale Lyapunov Exponent (FSLE) and the Lagrangian Structure Function (LSF), which both describe intrinsic physical properties at a given scale. We introduce a simple chaotic model for drifter motion in this system, and show by comparison with the model that Lagrangian dispersion is mainly driven by advection at sub-basin scales until saturation sets in

Network inference using asynchronously updated kinetic Ising Model

Network structures are reconstructed from dynamical data by respectively naive mean field (nMF) and Thouless-Anderson-Palmer (TAP) approximations. For TAP approximation, we use two methods to reconstruct the network: a) iteration method; b) casting the inference formula to a set of cubic equations and solving it directly. We investigate inference of the asymmetric Sherrington- Kirkpatrick (S-K) model using asynchronous update. The solutions of the sets cubic equation depend of temperature T in the S-K model, and a critical temperature Tc is found around 2.1. For T < Tc, the solutions of the cubic equation sets are composed of 1 real root and two conjugate complex roots while for T > Tc there are three real roots. The iteration method is convergent only if the cubic equations have three real solutions. The two methods give same results when the iteration method is convergent. Compared to nMF, TAP is somewhat better at low temperatures, but approaches the same performance as temperature increase. Both methods behave better for longer data length, but for improvement arises, TAP is well pronounced.Comment: 6 pages, 4 figure

Gaussian Belief with dynamic data and in dynamic network

In this paper we analyse Belief Propagation over a Gaussian model in a dynamic environment. Recently, this has been proposed as a method to average local measurement values by a distributed protocol ("Consensus Propagation", Moallemi & Van Roy, 2006), where the average is available for read-out at every single node. In the case that the underlying network is constant but the values to be averaged fluctuate ("dynamic data"), convergence and accuracy are determined by the spectral properties of an associated Ruelle-Perron-Frobenius operator. For Gaussian models on Erdos-Renyi graphs, numerical computation points to a spectral gap remaining in the large-size limit, implying exceptionally good scalability. In a model where the underlying network also fluctuates ("dynamic network"), averaging is more effective than in the dynamic data case. Altogether, this implies very good performance of these methods in very large systems, and opens a new field of statistical physics of large (and dynamic) information systems.Comment: 5 pages, 7 figure